Biologic therapies in patients with neuropsychiatric systemic lupus erythematosus.

Neuropsychiatric (NP) involvement is a prevalent and often severe feature of Systemic Lupus Erythematosus (SLE). Diverse factors are involved in its aetiopathogenesis and treating this condition is often quite challenging. However, clinical trials of biologic therapies in patients with SLE exclude those with severe NP manifestations. The place for the use of biologic approaches is thus even more problematic than it is for other aspects of SLE. Here we review the current evidence for the use of biologic therapies in the treatment of NPSLE.